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Home»Science»Research without lab animals? New tech is making it possible
Science

Research without lab animals? New tech is making it possible

June 6, 2025No Comments
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3-D: Short for three-dimensional. This term is an adjective for something that has features that can be described in three dimensions — height, width and length. 

animal model: A nonhuman animal used to stand in for people in research testing. Which animal a lab uses will depend on how closely parts of its body or chemical-signaling systems match those in people.

animal welfare: An idea that describes the quality of an animal’s life. Good animal welfare means that animals are safe, comfortable, healthy, well nourished, and can express their innate behaviors – things they are born knowing how to do.

artificial intelligence: A type of knowledge-based decision-making exhibited by machines or computers. The term also refers to the field of study in which scientists try to create machines or computer software capable of intelligent behavior.

aspirin: A common non-prescription drug, also known as acetylsalicylic acid. For more than a century, it has been widely used to treat headaches, joint pain, muscle pain, toothaches and more. It also reduces fevers and inflammation. Ancient papyrus texts indicate that as long as 5,000 years ago, the Sumerians and Egyptians were using willow bark (the source of aspirin’s active ingredient) to treat aches and pains.

biology: The study of living things. The scientists who study them are known as biologists.

computed-tomography scan: (CT, for short). A special kind of X-ray scanning that produces cross-sectional views of the inside of a bone or other internal tissues.

cell: (in biology) The smallest structural and functional unit of an organism. Typically too small to see with the unaided eye, it consists of a watery fluid surrounded by a membrane or wall. Depending on their size, animals are made of anywhere from thousands to trillions of cells.

chemical: A substance formed from two or more atoms that unite (bond) in a fixed proportion and structure. For example, water is a chemical made when two hydrogen atoms bond to one oxygen atom. Its chemical formula is H2O. Chemical also can be an adjective to describe properties of materials that are the result of various reactions between different compounds.

chronic: A condition, such as an illness (or its symptoms, including pain), that lasts for a long time.

compound: (often used as a synonym for chemical) A compound is a substance formed when two or more chemical elements unite (bond) in fixed proportions. For example, water is a compound made of two hydrogen atoms bonded to one oxygen atom. Its chemical symbol is H2O.

computer chip: (also integrated circuit) The computer component that processes and stores information.

Congress: The part of the U.S. federal government charged with writing laws, setting the U.S. budget, and confirming many presidential appointments to the courts, to represent the U.S. government interests overseas and to run administrative agencies.

COVID-19: A name given to the disease that erupted into a massive global pandemic in 2020. It first emerged in 2019 and is caused by a new coronavirus known as SARS-CoV-2. Symptoms can include pneumonia, trouble breathing, feeling too tired to walk more than a few steps, fever, headaches, low blood-oxygen levels, blood clots and brain “fog.”

criteria: (sing. criterion) The standards, rules, traits or other things used to make a judgment or determination about something.

culture: (v. in microbiology) To grow cells outside the body or their normal environment, usually in a beaker, a laboratory dish or some big vessel. To keep the cells healthy, they must be kept at the proper temperature, given the proper nutrients and provided ample room to grow.

database: An organized collection of related data.

develop: To emerge or to make come into being, either naturally or through human intervention, such as by manufacturing. (in biology) To grow as an organism from conception through adulthood, often undergoing changes in chemistry, size, mental maturity or sometimes even shape.

development: (in biology) The growth of an organism from conception through adulthood, often undergoing changes in chemistry, size and sometimes even shape.

gravity: The force that attracts anything with mass, or bulk, toward any other thing with mass. The more mass that something has, the greater its gravity.

heart attack: Permanent damage to the heart muscle that occurs when one or more regions of it become starved of oxygen, usually due to a temporary blockage in blood flow.

immune system: The collection of cells and their responses that help the body fight off infections and deal with foreign substances that may provoke allergies.

kidney: Each in a pair of organs in mammals that filters blood and produces urine.

liver: An organ of the body of animals with backbones that performs a number of important functions. It can store fat and sugar as energy, break down harmful substances for excretion by the body, and secrete bile, a greenish fluid released into the gut, where it helps digest fats and neutralize acids.

machine learning: A technique in computer science that allows computers to learn from examples or experience. Machine learning is the basis of some forms of artificial intelligence (AI). For instance, a machine-learning system might compare X-rays of lung tissue in people with cancer and then compare these to whether and how long a patient survived after being given a particular treatment. In the future, that AI system might be able to look at a new patient’s lung scans and predict how well they will respond to a treatment.

model: A simulation of a real-world event (usually using a computer) that has been developed to predict one or more likely outcomes. Or an individual that is meant to display how something would work in or look on others.

molecule: An electrically neutral group of atoms that represents the smallest possible amount of a chemical compound. Molecules can be made of single types of atoms or of different types. For example, the oxygen in the air is made of two oxygen atoms (O2), but water is made of two hydrogen atoms and one oxygen atom (H2O).

NASA: Short for the National Aeronautics and Space Administration. Created in 1958, this U.S. agency has become a leader in space research and in stimulating public interest in space exploration. It was through NASA that the United States sent people into orbit and ultimately to the moon. It also has sent research craft to study planets and other celestial objects in our solar system.

National Institutes of Health: (or NIH) This is one of the largest biomedical research organization in the world. A part of the U.S. government, it consists of 21 separate institutes — such as the National Cancer Institute and the National Human Genome Research Institute — and six additional centers. Most are located on a 300 acre facility in Bethesda, Md., a campus containing 75 buildings.

nerve: A long, delicate fiber that transmits signals across the body of an animal. An animal’s backbone contains many nerves, some of which control the movement of its legs or fins, and some of which convey sensations such as hot, cold or pain.

network: A group of interconnected people or things.

organ: (in biology) Various parts of an organism that perform one or more particular functions. For instance, an ovary is an organ that makes eggs, the brain is an organ that makes sense of nerve signals and a plant’s roots are organs that take in nutrients and moisture.

pandemic: An outbreak of disease that affects a large proportion of the population across much or most of the world. Among the most notable in recent decades was the years-long global COVID-19 pandemic, which was formally proclaimed by the World Health Organization on March 11, 2020. 

Parkinson’s disease: A disease of the brain and nervous system that causes tremors and affects movement, memory and mood. Certain genes make people susceptible to this disease, for which there is no cure.

rodent: A mammal of the order Rodentia, a group that includes mice, rats, squirrels, guinea pigs, hamsters and porcupines.

side effects: Unintended problems or harm caused by a procedure or treatment.

simulate: To deceive in some way by imitating the form or function of something. A simulated dietary fat, for instance, may deceive the mouth that it has tasted a real fat because it has the same feel on the tongue — without having any calories. A simulated sense of touch may fool the brain into thinking a finger has touched something even though a hand may no longer exists and has been replaced by a synthetic limb. (in computing) To try and imitate the conditions, functions or appearance of something. Computer programs that do this are referred to as simulations.

stem cell: A “blank slate” cell that can give rise to other types of cells in the body. Stem cells play an important role in tissue regeneration and repair.

system: A network of parts that together work to achieve some function. For instance, the blood, vessels and heart are primary components of the human body’s circulatory system. Similarly, trains, platforms, tracks, roadway signals and overpasses are among the potential components of a nation’s railway system. System can even be applied to the processes or ideas that are part of some method or ordered set of procedures for getting a task done.

technology: The application of scientific knowledge for practical purposes, especially in industry — or the devices, processes and systems that result from those efforts.

therapy: (adj. therapeutic) Treatment intended to relieve or heal a disorder.

tissue: Made of cells, it is any of the distinct types of materials that make up animals, plants or fungi. Cells within a tissue work as a unit to perform a particular function in living organisms. Different organs of the human body, for instance, often are made from many different types of tissues.

toxicity: (adj. toxic) A measure of the potential for some substance to poison or cause harm to living things. The harm may not occur immediately. Depending on the dose, organism and the toxic material, any harm may not show up for days, weeks or even years.

unique: Something that is unlike anything else; the only one of its kind.

vaccine: (v. vaccinate) A biological mixture that resembles a disease-causing agent. It is given to help the body create immunity to a particular disease. The injections used to administer most vaccines are known as vaccinations.

virtual: Being almost like something. An object or concept that is virtually real would be almost true or real — but not quite. The term often is used to refer to something that has been modeled by (or accomplished by) a computer using numbers, not by using real-world parts. So a virtual motor would be one that could be seen on a computer screen and tested by computer programming (but it wouldn’t be a three-dimensional device made from metal). (in computing) Things that are performed in or through digital processing and/or the internet. For instance, a virtual conference may be where people attended by watching it over the internet.

virus: Tiny infectious particles consisting of genetic material (RNA or DNA) surrounded by protein. Viruses can reproduce only by injecting their genetic material into the cells of living creatures. Although scientists frequently refer to viruses as live or dead, in fact many scientists argue that no virus is truly alive. It doesn’t eat like animals do, or make its own food the way plants do. It must hijack the cellular machinery of a living cell in order to survive.

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