Halpin HA, Morales-Suárez-Varela MM, Martin-Moreno JM. Chronic disease prevention and the new public health. Public Health Rev. 2010;32(1):120–54.
Zhou M, Wang H, Zeng X, Yin P, Zhu J, Chen W, et al. Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the global burden of disease study 2017. Lancet. 2019;394(10204):1145–58.
Zhao Y, Atun R, Oldenburg B, et al. Physical multimorbidity, health service use, and catastrophic health expenditure by socioeconomic groups in china: an analysis of Population-Based panel Data-All databases. Lancet Global Health. 2020;8(6):e840–9.
Hu Y, Wang Z, He H, Pan L, Tu J, Shan G. Prevalence and patterns of multimorbidity in China during 2002-2022: A systematic review and meta-analysis. Ageing Research Reviews. 2024;93:102165–80.
The Academy of Medical Sciences. Multimorbidity: a priority for global health research. London: Academy Of Medical Sciences; 2018.
Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of Multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012;380(9836):37–43.
Skou ST, Mair FS, Fortin M, et al. Multimorbidity Nat Rev Dis Primers. 2022;8(1):48.
The State Council Information Office of China. China implements gradual retirement age increase to address population aging. http://english.scio.gov.cn/chinavoices/2025-01/02/content_117641102.html. (17 January 2025, data last accessed).
Zhang X, Dupre ME, Qiu L, et al. Urban-rural differences in the association between access to healthcare and health outcomes among older adults in China. BMC Geriatr. 2017;17:151.
Xue L, Cai M, Liu Q, et al. Trends and regional variations in chronic diseases and their risk factors in china: an observational study based on National health service surveys. Int J Equity Health. 2023;22:120.
World Health Organization. Major NCDs and their risk factors. https://www.who.int/ncds/introduction/en/. (7 January 2025, data last accessed).
Steel N, Ford JA, Newton JN, et al. Changes in health in the countries of the UK and 150 english local authority areas 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet. 2018;392(10158):1647–61.
Pinto J, Bradbury K, Newell D, et al. Lifestyle and health behaviour change support in traditional acupuncture: a mixed method survey study of reported practice (UK). BMC Complement Med Ther. 2022;22(1):1–12.
Li Y, Schoufour J, Wang DD, Dhana K, Pan A, Liu X, et al. Healthy lifestyle and life expectancy free of cancer, cardiovascular disease, and type 2 diabetes: prospective cohort study. BMJ. 2020;368:l6669–79.
Ye X, Liang M, Chen Z, Jiang X, Xie M, Xie X, et al. Association between healthy lifestyle on life course and Multimorbidity in adults: results from two National prospective cohort studies. BMC Public Health. 2024;24(1):2942.
Zhong J, Chen L, Li C, Li J, Niu Y, Bai X, et al. Association of lifestyles and Multimorbidity with mortality among individuals aged 60 years or older: two prospective cohort studies. SSM Popul Health. 2024;26:101673.
Hu Y, Yang Y, Gao Y, et al. The impact of chronic diseases on the health-related quality of life of middle-aged and older adults: the role of physical activity and degree of digitization. BMC Public Health. 2024;24(1):2335.
LeMasters K, Renson A, Zalla L, Martin CL, Edwards JK. Understanding the accumulation of Health-Related inequities over the life course using the mean cumulative count. Am J Epidemiol. 2023;192(9):1425–31.
Li Q, Yang Z, Zhu M, et al. Prevalence and risk factors of osteoporotic fracture among the elderly population in china: a multicenter cross-sectional study. Int Orthop (SICOT). 2024;48(5):1323–30.
LV K, Liu Y, Zhang X, et al. Prevalence of chronic kidney disease in a City of Northwestern china: a cross-sectional study. Int Urol Nephrol. 2023;55(8):2035–45.
Freisling H, Viallon V, Lennon H, et al. Lifestyle factors and risk of Multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study. BMC Med. 2020;18:5.
Nguyen H, Chua KC, Dregan A, et al. Factors associated with Multimorbidity patterns in older adults in england: findings from the english longitudinal study of aging (ELSA). J Aging Health. 2020;32(9):1120–32.
Wister A, Cosco T, Mitchell B, Fyffe I. Health behaviors and Multimorbidity resilience among older adults using the Canadian longitudinal study on aging. Int Psychogeriatr. 2020;32(1):119–33.
Dong, Zhao. Key roles of five lifestyle risk factors in the harmful transition from a healthy condition to Multimorbidity in the Chinese population. Eur Heart J. 2021;42(34):7.
Ni W, Yuan X, Zhang Y, et al. Sociodemographic and lifestyle determinants of Multimorbidity among community-dwelling older adults: findings from 346,760 SHARE participants. BMC Geriatr. 2023;1:419.
Xing X, Yang X, Chen J, et al. Multimorbidity, healthy lifestyle, and the risk of cognitive impairment in Chinese older adults: a longitudinal cohort study. BMC Public Health. 2024;24:46.
Ho IS, Azcoaga-Lorenzo A, Akbari A, et al. Examining variation in the measurement of Multimorbidity in research: a systematic review of 566 studies. Lancet Public Health. 2021;6(8):e587–97.
Lin YW, Hu YD, Guo JH, Chen MJ, Xu XY, Wen YY, et al. Association between sleep and Multimorbidity in Chinese elderly: results from the Chinese longitudinal healthy longevity survey (CLHLS). Sleep Med. 2022;98:1–8.
Lim SS, Vos T,,Flaxman DA, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the global burden of disease study 2010. Lancet. 2013;380(9859):2224–60.
Hurst JR, Agarwal G, van Boven JFM, Daivadanam M, Gould GS, Huang EWC, et al. Critical review of Multimorbidity outcome measures suitable for low-income and middle-income country settings: perspectives from the global alliance for chronic diseases (GACD) researchers. BMJ Open. 2020;10(9):e037079.
Li BJ, Fan YJ, Bz A, Zhao BB, Yang LH, Yang J, et al. Later bedtime is associated with angina pectoris in middle-aged and older adults: results from the sleep heart health study. Sleep Med. 2021;79:1–5.
World Health Organization. Guidelines on physical activity and sedentary behaviour. https://www.who.int/publications/i/item/9789240015128. (7 April 2025, data last accessed).
General Administration of Sport of China. China issues national fitness plan for 2021–2025. http://www.china.org.cn/china/2021-08/08/content_77680600.htm. (7 April 2025, data last accessed).
National Health Commission of the People’s Republic of China. Notice of the General Office of the National Health Commission of the People’s Republic of China on the issuance of nutrition and exercise guidelines for chronic diseases such as hypertension (2024 edition). https://www.gov.cn/zhengce/zhengceku/202407/content_6960475.htm. (7 April 2025, data last accessed).
National Health Commission of the People’s Republic of China. Notice of the General Office of the National Health Commission on Issuing the Guiding Principles for Weight Management. (2024 Edition).http://www.nhc.gov.cn/ylyjs/s3573d/202412/4cf1905d32304c15ac3bc4446ddb83f1.shtml. (7 April 2025, data last accessed).
Fisher K, Griffith LE, Gruneir A, Kanters D, Markle-Reid M, Ploeg J. Functional limitations in people with Multimorbidity and the association with mental health conditions: baseline data from the Canadian longitudinal study on aging (CLSA). PLoS ONE. 2021;16(8):e0255907.
Mulder JD, Hamaker EL. Three extensions of the random intercept Cross-Lagged panel model. Struct Equation Modeling: Multidisciplinary J. 2020;28(4):638–48.
Constandt B, Thibaut E, De Bosscher V, Scheerder J, Ricour M, Willem A. Exercising in times of lockdown: an analysis of the impact of COVID-19 on levels and patterns of exercise among adults in Belgium. Int J Environ Res Public Health. 2020;17(11):4144.
Faulkner J, O’Brien WJ, McGrane B, Wadsworth D, Batten J, Askew CD, et al. Physical activity, mental health and well-being of adults during initial COVID-19 containment strategies: A multi-country cross-sectional analysis. J Sci Med Sport. 2021;24(4):320–6.
Sepúlveda-Loyola W, Rodríguez-Sánchez I, Pérez-Rodríguez P, Ganz F, Torralba R, Oliveira DV, et al. Impact of social isolation due to COVID-19 on health in older people: mental and physical effects and recommendations. J Nutr Health Aging. 2020;24(9):938–47.
Zheng Z, Peng F, Xu B, Zhao J, Liu H, Peng J, et al. Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis. J Infect. 2020;81(2):e16–25.
Hirko KA, Kerver JM, Ford S, Szafranski C, Beckett J, Kitchen C, et al. Telehealth in response to the COVID-19 pandemic: implications for rural health disparities. J Am Med Inf Assoc. 2020;27(11):1816–8.
Karaye IM, Horney JA. The impact of social vulnerability on COVID-19 in the U.S.: an analysis of spatially varying relationships. Am J Prev Med. 2020;59(3):317–25.
Hale T, Angrist N, Goldszmidt R, et al. A global panel database of pandemic policies (Oxford COVID-19 government response Tracker). Nat Hum Behav. 2021;5:529–38.
Podsakoff PM, Organ DM. Self-reports in organizational research: problems and prospects. J Manag. 1986;12(4):531–44.
Podsakoff PM, MacKenzie SB, Lee JY, Podsakoff NP. Common method biases in behavioral research: a critical review of the literature and recommended remedies. J Appl Psychol. 2003;88(5):879–903.
Falkenström F, Solomonov N, Rubel JA. How to model and interpret cross-lagged effects in psychotherapy mechanisms of change research: A comparison of multilevel and structural equation models. J Consult Clin Psychol. 2022;90(5):446–58.
Griffin SC, Ravyts SG, Bourchtein E, Ulmer CS, Leggett MK, Dzierzewski JM, et al. Sleep disturbance and pain in U.S. Adults over 50: evidence for reciprocal, longitudinal effects. Sleep Med. 2021;86:32–9.
Keessen P, Kan KJ, Ter Riet G, Visser B, Jørstad HT, Latour CHM, et al. The longitudinal relationship between fear of movement and physical activity after cardiac hospitalization: A cross lagged panel model. PLoS ONE. 2024;19(4):e0297672.
Sun Q, Yu D, Fan J, Yu C, Guo Y, Pei P, et al. Healthy lifestyle and life expectancy at age 30 years in the Chinese population: an observational study. Lancet Public Health. 2022;7(12):e994–1004.
Zhang YX, Zhou L, Liu SY, Qiao YN, Wu Y, Ke CF, Shen YP. Prevalence, correlates and outcomes of Multimorbidity among the middle-aged and elderly: findings from the China health and retirement longitudinal study.archives of gerontology and geriatrics: an international journal integrating experimental. Clin Social Stud Ageing. 2020;90(1):1–6.
Chakravarti D, LaBella KA, DePinho RA. Telomeres: history, health, and hallmarks of aging. Cell. 2021;184(2):306–22.
Keshavarz M, Xie K, Schaaf K, Bano D, Ehninger D. Targeting the hallmarks of aging to slow aging and treat age-related disease: fact or fiction? Mol Psychiatry. 2023;28(1):242–55.
Liu Y, Wang J, Huang Z, Liang J, Xia Q, Xia Q, Liu X. Environmental pollutants exposure: A potential contributor for aging and age-related diseases. Environ Toxicol Pharmacol. 2021;83:103575.
Nevalainen T, Kananen L, Marttila S, Jylhävä J, Mononen N, Kähönen M, Raitakari OT, Hervonen A, Jylhä M, Lehtimäki T, Hurme M. Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals. Clin Epigenetics. 2017;9:20.
Johnson AA, Akman K, Calimport SR, Wuttke D, Stolzing A, de Magalhães JP. The role of DNA methylation in aging, rejuvenation, and age-related disease. Rejuvenation Res. 2012;15(5):483–94.
Sakib MN, Shooshtari S, St JP, Menec V. The prevalence of Multimorbidity and associations with lifestyle factors among middle-aged canadians: an analysis of Canadian longitudinal study on aging data. BMC Public Health. 2019;19(1):243.
Wu F. Intergenerational support and life satisfaction of older parents in china: A Rural–Urban divide. Soc Indic Res. 2022;160:1071–98.
Wu Y, Gong C, Pi L, Zheng M, Liu W, Wang Y. Interrelationships among individual factors, family factors, and quality of life in older Chinese adults: Cross-Sectional study using structural equation modeling. JMIR Aging. 2024;7:e59818.
Burnier M. The role of adherence in patients with chronic diseases. Eur J Intern Med. 2024;119:1–5.
Bandura A. Self-efficacy: toward a unifying theory of behavioral change. Psychol Rev. 1977;84(2):191–215.
Chen J, Tian Y, Yin M, Lin W, Tuersun Y, Li L, Yang J, Wu F, Kan Y, Li X, Gan Y, Sun X, Wu Y, He F. Relationship between self-efficacy and adherence to self-management and medication among patients with chronic diseases in china: A multicentre cross-sectional study. J Psychosom Res. 2023;164:111105.
María José Martos-Méndez. Self-efficacy and adherence to treatment: the mediating effects of social support. J Behav Health Social Issues. 2015;7(2):19–29.
Yin H, Knowlton B. The role of the basal ganglia in habit formation. Nat Rev Neurosci. 2006;7:464–76.
Chen X, Ai C, Liu Z, et al. Neuroimaging studies of resting-state functional magnetic resonance imaging in eating disorders. BMC Med Imaging. 2024;24:265.
Wyatt Z. The neuroscience of habit formation. Neurol Neurosci. 2024;5(1):3.
Sum G, Lau LK, Jabbar KA, Lun P, George PP, Munro YL, Ding YY. The world health organization (WHO) integrated care for older people (ICOPE) framework: A narrative review on its adoption worldwide and lessons learnt. Int J Environ Res Public Health. 2022;20(1):154.
Zhou Y, Zhou Y, Li L, Jin L. How to encourage consumers’ ongoing participation in physical exercise via feedback: evidence from a longitudinal field experiment. China Econ Rev. 2024;88:102268.
Blandford A, Wesson J, Amalberti R, AlHazme R, Allwihan R. Opportunities and challenges for telehealth within, and beyond, a pandemic. Lancet Glob Health. 2020;8(11):e1364–5.
Fan K, Zhao Y. Mobile health technology: a novel tool in chronic disease management. Intell Med. 2022;2(1):41–7.
Novara G, Checcucci E, Crestani A, et al. Telehealth in urology: A systematic review of the literature. How much can telemedicine be useful during and after the COVID-19 pandemic? Eur Urol. 2020;78(6):786–811.
World Health Organization. Atlas eHealth Country Profiles: Based on the Findings of the Second Global Survey on Ehealth. https://apps.who.int/iris/handle/10665/44502. (7 April 2025, data last accessed).
Wang Q, Zhang K, Zhang X, Fu J, Liu F, Gao Y, Lin R. WeChat mini-program, a preliminary applied study of the gestational blood glucose management model for pregnant women with gestational diabetes mellitus. Diabetes Res Clin Pract. 2025;219:111943.
Ma X, Fan W, Zhang X, et al. The urban-rural disparities and factors associated with the utilization of public health services among diabetes patients in China. BMC Public Health. 2023;23:2290.
Tan XQ. The role of healthy lifestyles in preventing chronic disease among adults. Am J Med Sci. 2022;364(3):309–15.
Tan MMC, Barbosa MG, Pinho PJMR, Assefa E, Keinert AÁM, Hanlon C, et al. Determinants of Multimorbidity in low- and middle-income countries: A systematic review of longitudinal studies and discovery of evidence gaps. Obes Rev. 2024;25(2):e13661.
McCracken C, Raisi-Estabragh Z, Szabo L, Robson J, Raman B, Topiwala A, et al. NHS health check attendance is associated with reduced multiorgan disease risk: a matched cohort study in the UK biobank. BMC Med. 2024;22(1):1.
Berner K, Tawa N, Louw Q. Multimorbidity patterns and function among adults in low- and middle-income countries: a scoping review protocol. Syst Rev. 2022;11(1):139.
Zhang X, Padhi A, Wei T, Xiong S, Yu J, Ye P, et al. Community prevalence and dyad disease pattern of Multimorbidity in China and india: a systematic review. BMJ Glob Health. 2022;7(9):e008880.
Zhang X, Liu T, Li Z, Yang J, Hou H, Hao T, et al. Using primary and routinely collected data to determine prevalence and patterns of Multimorbidity in rural china: a representative cross-sectional study of 6474 Chinese adults. Lancet Reg Health West Pac. 2024;54:101272.
Krause AJ, Vallat R, Simon EB, Walker MP. Sleep loss influences the interconnected brain-body regulation of cardiovascular function in humans. Psychosom Med. 2023;85:34–41.